Influence of socioeconomic development on incidence and disease phenotype in inflammatory bowel disease: a population-based incident study across 16 regions.

Authors

Joyce W Y Mak, Agnes H Y Ho, Alicia K W Chan, Yinglei Miao, Yang Sun, Hang Viet Dao, Jamilya Kaibullayeva, Mukesh Sharma Paudel, Julajak Limsrivilai, Shu Chen Wei, Mansour Altuwaijri, Murdani Abdullah, Jesus K Yamamoto-Furusho, Domingo Balderramo, Raja Affendi Raja Ali, Ida Hilmi, Ka Kei Ng, Paul Kelly, Vui Heng Chong, Beatriz Iade Vergara, Yee Kit Tse, Ivan S F Lau, Julia Gorospe, Lindsay Hracs, Stephanie Coward, Joseph W Windsor, Gilaad G Kaplan, Siew C Ng, GIVES-21 Consortium

Published in

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. Sep 08, 2026. Epub Sep 08, 2026.

Abstract

The global rise in inflammatory bowel disease (IBD) parallels socio-economic development, but its influence on disease epidemiology and phenotype remains unclear. We aimed to characterise IBD incidence, clinical features, and associations with socio-economic indices across newly industrialised countries.
This prospective population-based study spanned 16 regions in Africa, Asia, Latin America, and the Middle East from October 2021 for one year. Poisson regression estimated incidence rate ratios (IRR) for Human Development Index (HDI), Socio-demographic Index (SDI), subnational HDI, and urban population percentage. Mixed-effects models examined associations with disease phenotype, activity, and treatment.
Of 606 incident cases (229 Crohn's disease [CD], 348 ulcerative colitis [UC], 29 IBD-unclassified), incidence varied widely. Hong Kong had the highest crude annual incidence (IBD 7.43; CD 2.69; UC 3.44) and Vietnam the lowest (0.13; 0.04; 0.08). Urban population (per 10% increase) was associated with higher incidence of IBD (IRR 1.68), CD (1.73), and UC (1.62). HDI and SDI significantly correlated with CD (IRR 4.05 and 2.96, respectively), but not subnational HDI. Higher HDI and subnational HDI were associated with increased odds of perianal CD (adjusted OR 2.61 and 2.40). Other disease phenotype, activity, and treatment pattern were not significantly linked to any index.
Higher urbanisation and development are associated with higher IBD incidence, particularly CD, but not with disease activity at diagnosis. Notably, perianal CD was more common in regions with higher HDI and subnational HDI, suggesting an association with regional socioeconomic development. These highlight the need for region-specific early diagnosis strategies.

PMID:
42710770
Bibliographic data and abstract were imported from PubMed on 09 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.