Collagen Prolyl 4-Hydroxylase: An Emerging Key Player in Cardiac Fibrosis.

Authors

Wei Hua, Zai-Xin Yu, Li-Huang Zha

Published in

Journal of cardiovascular translational research. Volume 19. Issue 1. Sep 08, 2026. Epub Sep 08, 2026.

Abstract

Collagen prolyl 4-hydroxylase (C-P4H) is a key enzyme that controls collagen maturation and fibrotic matrix buildup. Cardiac fibrosis is a major pathological basis of many cardiovascular diseases. It is marked by excess collagen deposition and extracellular matrix stiffening, which lead to myocardial stiffness and progression to heart failure. Growing evidence shows that C-P4H and its related subunits are abnormally expressed in several cardiac diseases linked to fibrosis and are closely associated with disease development. C-P4H regulates intracellular procollagen maturation and secretion and thereby indirectly influences extracellular matrix remodeling. Targeting C-P4H has also shown antifibrotic effects in several fibrosis models, which suggests that this enzyme may serve as a potential therapeutic target in cardiac fibrosis. In this review, we briefly summarize the structure and function of C-P4H, discuss its regulatory roles in the development of cardiac fibrosis, and outline the therapeutic prospects of targeting C-P4H.

PMID:
42711444
Bibliographic data and abstract were imported from PubMed on 09 Sep 2026.

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