Deprotective Alkylation: A Platform for Alcohol-to-Amine Interconversion Using Nonafluoromesitylenesulfonamides.

Authors

Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide

Published in

Angewandte Chemie (International ed. in English). Pages e3520541. Sep 08, 2026. Epub Sep 08, 2026.

Abstract

The direct conversion of alcohols to amines remains a long-standing challenge in organic synthesis. In this study, we report a practical approach, based on the concept of deprotective functionalization, for the stereospecific synthesis of secondary and tertiary amines in high yields directly from alcohol precursors and Nms-amides. Our approach exploits the distinct reactivity of Nms-amides and has the potential to reduce step count in synthetic sequences. The versatility of the method is showcased through applications in late-stage functionalization and the efficient preparation of isotopically labeled compounds.

PMID:
42711760
Bibliographic data and abstract were imported from PubMed on 09 Sep 2026.

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