Authors
Meghan E Vogt, Anne Z Murphy
Published in
Psychopharmacology. Sep 09, 2026. Epub Sep 09, 2026.
Abstract
Nearly one third of women of reproductive age in the United States are prescribed opioids annually; 14% will fill an opioid prescription during pregnancy, and one in five report misuse. Opioid use during pregnancy has given rise to an increasing population of infants born with gestational opioid exposure. At school age, these children show neurodevelopmental impairment and higher rates of learning disabilities.
To characterize how exposure to exogenous opioids during brain development affects learning and memory performance, our lab has developed a rat model of perigestational opioid exposure that closely recapitulates a clinically relevant dosing timeline by beginning morphine exposure before pregnancy and continuing through the first postnatal week.
Male and female offspring generated from this model were assessed on several facets of learning and memory during adolescence.
Here, we report that morphine exposure selectively impaired spatial learning, as measured by the Barnes Maze, and associative learning, as measured by an Attentional Set Shift Task, without significantly impacting working or short-term memory. Environmental enrichment rescued the spatial learning deficit in males but not females.
Our findings suggest that gestational opioid exposure can impair performance in complex cognitive tasks, and non-invasive, non-pharmacological intervention may attenuate these deficits.
PMID:
42711522
Bibliographic data and abstract were imported from PubMed on 09 Sep 2026.
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