An Ag(I)-catalyzed dearomatizing spirocyclization/allylation cascade: synthesis of allylated spiroindolines from indole-tethered ynones.

Authors

Pallavi Phadatare, Sheetal Saini, Debojyoti Bag, Sanghapal D Sawant

Published in

Chemical communications (Cambridge, England). Sep 09, 2026. Epub Sep 09, 2026.

Abstract

Herein, we report an Ag(I)-catalyzed strategy for the synthesis of C2 allylated spiroindolines from indole-tethered ynones and allyltri-methylsilanes. The developed protocol involves a 5-/6-endo-dig dearomatizing spirocyclization of indole-tethered ynones, followed by nucleophilic allylation of the resulting spiroindolenine intermediate using diverse allyltrimethylsilanes. This transformation enables the formation of two new C-C bonds and two contiguous stereocenters with excellent diastereoselectivity.

PMID:
42714304
Bibliographic data and abstract were imported from PubMed on 09 Sep 2026.

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