Authors
Li Zhang, Zhenghong Peng, Tianqi Tu
Published in
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. Pages 271678X261478954. Sep 09, 2026. Epub Sep 09, 2026.
Abstract
Middle meningeal artery embolization (MMAE) has rapidly evolved from a procedure targeting specific vascular pathologies into a versatile therapeutic strategy with expanding indications across neurological diseases. However, the biological mechanisms underlying its cross-disease efficacy remain poorly defined.
We synthesized experimental and clinical studies across emerging MMAE indications, including chronic subdural hematoma, migraine, and glioblastoma, with a focus on identifying shared neurovascular-immune mechanisms.
Emerging evidence suggests that the middle meningeal artery (MMA) functions as a neurovascular-immune interface that integrates nociceptive signaling, neurogenic inflammation, pathological angiogenesis, and meningeal immune regulation. Within this framework, MMAE exerts therapeutic effects beyond vascular occlusion by disrupting pathological blood supply, attenuating neurogenic inflammation, modulating aberrant angiogenesis, and reshaping the meningeal immune microenvironment. These coordinated actions provide a unifying mechanistic basis for its efficacy across distinct disease contexts.
This review proposes an integrated conceptual framework linking MMAE to neurovascular-immune regulation, thereby advancing its understanding as a strategy for modulating disease-relevant microenvironmental interactions across neurological disorders.
PMID:
42713835
Bibliographic data and abstract were imported from PubMed on 09 Sep 2026.
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