Pleural effusion caused by Rickettsia felis infection.

Authors

Hong Ren, Yingying Zhang, Xue Zhang, Hanwen Zhang, Li Chang, Lingyun Gao, Lin Li, Gaoyang Zhang

Published in

Journal of infection in developing countries. Volume 20. Issue 8. Pages 1256-1259. Aug 31, 2026. Epub Aug 31, 2026.

Abstract

Rickettsia felis, a Gram-negative obligate intracellular prokaryotic organism, causes human infections with atypical clinical presentations, commonly including fever, fatigue, headache, and maculopapular rash.
This study presents a rare case of pleural effusion (PE) associated with R. felis infection, confirmed through targeted next-generation sequencing (tNGS). The patient showed significant clinical improvement and resolution of PE following empirical moxifloxacin followed by pathogen-directed therapy with rifampicin and azithromycin, along with supportive measures for circulation and immune function.
This case report aims to enhance early diagnosis and therapeutic strategies for R. felis infections by sharing the diagnostic and management experience.

PMID:
42715280
Bibliographic data and abstract were imported from PubMed on 10 Sep 2026.

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