Authors
Labony Khandokar, Yessica Santana Agreda, Bridget M Curran, Le Ma, Kevin M Wright, Patrick C Kerstein
Published in
Developmental biology. Sep 09, 2026. Epub Sep 09, 2026.
Abstract
Within the neuronal classes of the retina, amacrine cells (ACs) exhibit the greatest neuronal diversity in morphology and function. We show that the selective expression of the transcription factor Gbx2 is required for dendritic stratification of an individual AC subtype in the mouse retina. We identify Robo1 and Robo2 as downstream effectors that when deleted, phenocopy the dendritic misprojections seen in Gbx2 mutants. Slit1 and Slit2, the ligands of Robo receptors, are localized to the upper layers of the inner plexiform layer where we observe the dendritic misprojections in both Gbx2 and Robo1/2 mutants. We show that Robo receptors also are required for the proper dendritic stratification of additional AC subtypes, such as Vglut3+ ACs. These results show both that Gbx2 regulates the terminal differentiation of a single AC subtype and identify Slit-Robo signaling as a developmental mechanism for dendrite stratification in the retina.
PMID:
42716364
Bibliographic data and abstract were imported from PubMed on 10 Sep 2026.
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