Authors
Mei Yuan, Yueyuan Hou, Luohua Li
Published in
The American journal of the medical sciences. Sep 09, 2026. Epub Sep 09, 2026.
Abstract
Epidemiological evidence on the relationship between the Healthy Eating Index (HEI-2015) and mortality in chronic kidney disease (CKD) populations is limited. This study aimed to assess the association between HEI-2015 scores and all-cause mortality in CKD patients.
This cohort study included 7,360 CKD patients using data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018, with follow-up until December 31, 2019. All-cause mortality was determined using National Death Index (NDI) records. We applied weighted Cox regression models to estimate the hazard ratio (HR) and 95% confidence interval (CI) between HEI-2015 and all-cause mortality.
Over a median follow-up of 78 months, 2,437 CKD patients died from all causes. After adjusting for confounders, individuals in the highest tertile of HEI-2015 scores had a lower risk of all-cause mortality compared to those in the lowest tertile, with an HR of 0.55 (95% CI: 0.34-0.89). Additionally, each standard deviation increase in HEI-2015 was associated with an HR of 0.73 (95% CI: 0.60-0.90) for all-cause mortality. Kaplan-Meier survival and restricted cubic regression spline analyses revealed a significant negative correlation between HEI-2015 and mortality risk (P<0.05), which was supported by sensitivity analysis.
Higher HEI-2015 scores are significantly associated with a reduced risk of mortality in CKD patients, highlighting the importance of improving HEI-2015 scores in high-risk CKD populations to reduce mortality risk.
PMID:
42716882
Bibliographic data and abstract were imported from PubMed on 10 Sep 2026.
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