Comparative adjuvant therapy to reduce vancomycin-associated nephrotoxicity in an animal model.

Authors

Yongqi Xiao, Nicholas S Teran, Cole S Hudson, Masayuki Nigo, Vincent H Tam

Published in

Antimicrobial agents and chemotherapy. Pages e0088726. Sep 10, 2026. Epub Sep 10, 2026.

Abstract

Vancomycin is a mainstay antibiotic for serious gram-positive infections, but nephrotoxicity remains a major barrier to its optimal use. In this study, we compared the effectiveness of montelukast and zileuton as adjuvant strategies to reduce vancomycin-associated nephrotoxicity. Montelukast only had a marginal effect in vancomycin-treated animals, whereas zileuton significantly delayed nephrotoxicity onset. These findings support further formulation and dose-optimization studies to repurpose zileuton as a renal-protective adjuvant.

PMID:
42720563
Bibliographic data and abstract were imported from PubMed on 10 Sep 2026.

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