Genetic Diagnosis in Epilepsy: Implications for Clinical Management.

Authors

Krista S Schatz, Dawn B Lammert, Christa W Habela

Published in

Current neurology and neuroscience reports. Volume 26. Issue 1. Sep 10, 2026. Epub Sep 10, 2026.

Abstract

To describe the clinical implications of genetic diagnoses in epilepsy and the recent advancements in this field.
A genetic diagnosis in epilepsy has been shown to impact clinical management in almost half of individuals, often within three months of diagnosis, with anti-seizure medication recommendations being the most common change. More recently, data from somatic genetic testing in brain tissue has shown the potential to impact prognostic information and medication recommendations. Genetic testing is becoming routine clinical care in epilepsy and is recommended for all individuals with unexplained epilepsy, regardless of age. A monogenic epilepsy diagnosis impacts clinical seizure management and provides additional non-seizure management benefits. The clinical utility of genetic testing will only continue to increase as gene therapies and other precision medicine treatments are approved.

PMID:
42720877
Bibliographic data and abstract were imported from PubMed on 11 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.