[Unresectable Gastric Cancer Achieving pCR Via Conversion Surgery after Chemotherapy-Implications for Optimizing Individualized Treatment].

Authors

Naoi Sato, Tatsuya Tanaka, Fuka Fujimoto, Haruka Kirihara, Ryo Nakajima, Shigeyuki Kosaka, Shinnosuke Harata, Kaori Watanabe, Kazuyoshi Shiga, Tomoya Shamoto, Hiroyuki Sagawa, Yoichi Matsuo, Shuji Takiguch

Published in

Gan to kagaku ryoho. Cancer & chemotherapy. Volume 53. Issue 8. Pages 530-532.

Abstract

A patient was diagnosed with T4aN+ Stage Ⅲ gastric cancer. After 2 courses of SOX chemotherapy for initially unresectable disease. Additional pathological evaluation revealed tumor PD-L1 (22C3) CPS≥10, HER2 1+, Claudin18 negative status, and MSI negative. Consequently, 2 courses of SOX plus nivolumab were administered. Post-treatment CT revealed resectability, thus leading to robot-assisted distal gastrectomy with D2 lymph node dissection and Billroth-Ⅱ reconstruction was performed. Postoperative pathology showed no residual tumor cells in the primary lesion or lymph nodes, confirming a pCR (ypT0N0). The postoperative course was uneventful and there were no major complications. At 5 months postoperatively, no recurrence was detected and SOX chemotherapy is currently being administered as postoperative adjuvant therapy.

PMID:
42723242
Bibliographic data and abstract were imported from PubMed on 11 Sep 2026.

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