Research advances on postbiotics in promoting skin wound healing: mechanisms, formulations, and clinical translation.

Authors

Yu Xing, Jinyu Song, Bingbing Shang, Guangdi Yang, Ye Zhao, Ming Li, Binbin Hou

Published in

Frontiers in immunology. Volume 17. Pages 1912496. Epub Aug 27, 2026.

Abstract

Wound healing is a complex process involving different cell types, molecules and stages in the dermis, epidermis and associated microbiome. Chronic wounds caused by pressure, diabetes, or immunodeficiency often have huge economic and therapeutic costs. Postbiotics, in particular inactivated bacteria, cell components and metabolites, are emerging as novel treatments targeting the skin microbiome and provide precise treatment options for wound healing, inflammation, angiogenesis and re-epithelialization. We review the positive regulatory role of different microbial communities in skin healing; evaluate evidence and mechanisms of various postbiotics, in vitro and in vivo models as well as preliminary clinical studies; and summarize progress in the translation of postbiotics for skin wound repair.

PMID:
42724718
Bibliographic data and abstract were imported from PubMed on 11 Sep 2026.

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