Lumateperone-induced mania: A case series.

Authors

Varchasvi Mudgal, Prashant Gaurav, Priyash Jain, Kartikay Chaturvedi

Published in

Indian journal of psychiatry. Volume 68. Issue 8. Pages 761-764. Epub Aug 20, 2026.

Abstract

Lumateperone is an approved treatment for bipolar depression with a low reported risk of treatment-emergent mania. However, real-world evidence remains limited.
We describe three adults with bipolar depression who developed manic symptoms within 10-14 days of initiating lumateperone 42 mg/day. Young Mania Rating Scale scores ranged from 26 to 29. Alternative causes were excluded, symptoms resolved after discontinuing lumateperone and optimizing mood stabilizers, and Naranjo scores (7-8) indicated a probable drug association.
Lumateperone may precipitate mania in susceptible individuals, highlighting the need for close monitoring during the early treatment period.

PMID:
42724943
Bibliographic data and abstract were imported from PubMed on 11 Sep 2026.

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