B cell responses to CD40 stimulation ignite anti-tumor immunity by activating CD8⁺ T cell cytotoxicity.

Authors

Kendrick Nguyen, Monika Quackenbush, Sara Basbous, Haley Rodriguez, Georgia Lattanzi, Elsie Quansah, Chynna Bowman, Sammy Weiser Novak, Daniela Boassa, Jingting Yu, Taylor Ozbun, Asona Lui, Aatish Thennavan, Peter Watson, April Wehner, Daniel Hollern

Published in

Cell reports. Volume 45. Issue 9. Pages 117957. Sep 10, 2026. Epub Sep 10, 2026.

Abstract

B cell responses to cancer are critical to patient survival and response to therapy. Yet, the knowledge as to how B cells can elicit anti-tumor immunity remains incomplete. We identify that CD40 pathway activation in B cells in the presence of high tumor mutation burdens activates an anti-tumor B cell response. Significantly, our study shows that CD40-stimulated B cells drive tumor infiltration, organization, and activation of cytotoxic function in CD8⁺ T cells. These results provide key advances in the mechanistic regulation and function of B cell and CD8⁺ T cell responses to cancer.

PMID:
42726639
Bibliographic data and abstract were imported from PubMed on 12 Sep 2026.

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