Nutraceuticals: A strategy to mitigate neurotoxicity.

Authors

Fatemeh Rahmati-Dehkordi, Zeinab Tamtaji, Ehsan Dadgostar, Michael Aschner, Fatemeh Nabavizadeh, Hamed Mirzaei, Omid Reza Tamtaji

Published in

Advances in neurotoxicology. Volume 15. Issue 1. Pages 147-186. Epub May 20, 2026.

Abstract

Increased evidence from epidemiological research and pre-clinical studies have presented a correlation between exogenous neurotoxicants (such as aluminum, arsenic, lead, cadmium, mercury and ethanol) and various neurobiological disorders which contribute to cognitive impairments. The existing data demonstrate that nutraceutical supplementation affords neuroprotective effects against neurotoxicity. Nutraceuticals improved learning and memory impairments, anxiety and depressive-like behavior, locomotor activity and neuropathic pain. The most common molecular and cellular mechanisms in nutraceutical therapy include attenuation of oxidative stress (by suppressing lipid peroxidation and increasing antioxidant enzymes and contents), suppression of apoptosis (by increasing B-cell lymphoma 2 (Bcl2) expression, and reduction in Bcl-2-associated X protein (Bax), caspase-3 and cytochrome c expression), suppression of neuroinflammation (by inhibiting inflammatory cytokines), inhibition of amyloid β (Aβ) plaque and neurofibrillary tangles, and increased synaptic plasticity (by increasing Brain-derived neurotrophic factor (BDNF), and regulating cholinergic and neurotransmitter systems.

PMID:
42273011
Bibliographic data and abstract were imported from PubMed on 12 Sep 2026.

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