Post-TB lung disease: pathogenesis, host-directed therapies, and the C3HeB/FeJ model for pre-clinical advances.

Authors

Boatema Ofori-Anyinam, Brian Nyiro, Padmini Salgame

Published in

Infection and immunity. Volume 94. Issue 3. Pages e0052324. Mar 10, 2026. Epub Feb 09, 2026.

Abstract

More than half of the people with microbiologically cured tuberculosis (TB) present with post-TB lung disease (PTLD). PTLD compromises long-term respiratory health and adds to the global burden of chronic lung diseases. Despite its prevalence, the mechanisms driving tissue damage in TB are not well understood. In this review, we discuss the global burden of PTLD, evaluate host-directed therapies as promising interventions, and highlight the C3HeB/FeJ mouse model as a powerful tool for advancing pre-clinical PTLD research.

PMID:
41661106
Bibliographic data and abstract were imported from PubMed on 12 Sep 2026.

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