Resolving tooth development at single-cell resolution: advancing dental regeneration.

Authors

Chengcheng Liao, Jun Cai, Yanmei Liu, Linlin Xiao, Mingli Xiang, Man Qu, Qian Long, Meiling Xiang, Sicen Long, Houli Peng, Jianguo Liu, Xiaoyan Guan

Published in

Frontiers in cell and developmental biology. Volume 14. Pages 1785805. Epub Mar 12, 2026.

Abstract

Tooth development is a continuous, highly orchestrated process that serves as an ideal model for dissecting the cellular and molecular mechanisms of organogenesis. In recent years, advances in single-cell transcriptomics have provided unprecedented insights into cellular heterogeneity, lineage trajectories, and molecular signaling networks during mouse and human tooth development, greatly enhancing our understanding of odontogenesis. Crucially, these single-cell-level studies of tooth development provide both a theoretical foundation and advanced strategies for dental tissue regeneration.

PMID:
41909121
Bibliographic data and abstract were imported from PubMed on 12 Sep 2026.

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