Self-Enhancing Photodynamic / Immunotherapy via a MOF Nanoplatform for Combined STING Activation and Immune Checkpoint Blockade.

Authors

Bei Liu, Jiayi Zhang, Wenfei Xu, Yuechen Liu, Nawei Wu, Hongshang Peng, Hongxia Li, Zhaogang Sun, Hongqian Chu

Published in

Advanced healthcare materials. Pages e71714. Sep 11, 2026. Epub Sep 11, 2026.

Abstract

Combinational photodynamic and immune checkpoint blockade (PDT/ICB) therapy is a promising approach for oncotherapy. However, the tumor microenvironment (TME) poses multiple biological barriers that can critically undermine the treatment outcomes of PDT/ICB. To this end, a cascade-amplified photodynamic immunotherapy nanoplatform based on the core-shell structured metal-organic frameworks (MOFs) was elaborately constructed. This nanoplatform, termed PMA, was constructed by growing manganese oxide (MnO₂) layer on a porphyrinic MOF core, followed by conjugation with PD-L1-targeting aptamers. Upon reaching the tumor, the MnO₂ shell scavenges glutathione (GSH) while concurrently releasing O₂ for hypoxia alleviation and Mn²⁺ ions as STING agonists. Simultaneously, MOF-based core was directly self-assembled from porphyrin photosensitizers (PSs) and metal clusters, resulting in high PSs loading capacity without self-quenching. More importantly, the liberated PD-L1 aptamers block immune checkpoint interactions, reversing local immunosuppression and activating cytotoxic T lymphocytes. Together, this multimodal strategy evokes robust antitumor immunity, offering a powerful and translatable approach to expand the scope of cancer immunotherapy.

PMID:
42728241
Bibliographic data and abstract were imported from PubMed on 12 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.