Incidence and baseline predictors of discontinuation in DRCRnet studies.

Authors

Klyve N Otinkorang, Gui-Shuang Ying

Published in

Eye (London, England). Sep 11, 2026. Epub Sep 11, 2026.

Abstract

To evaluate the incidence and baseline predictors of participant discontinuation in Diabetic Retinopathy Clinical Research Retina Network (DRCRnet) studies METHODS: Using the publicly available DRCRnet data, discontinuation rate and its 95% confidence intervals (95% CI) were calculated. Univariable and multivariable logistic regression models were used to assess predictors for participant discontinuation, including demographic, clinical, and study design characteristics, and within-study correlation was accounted for using generalised estimating equations.
Among 7353 participants (mean age 60 years, 48.0% female, 64.1% non-Hispanic (NH)-White, 17.8% NH-Black, 14.2% Hispanic), 1110 participants (15.1%, 95% CI 14.3-15.9%) discontinued study participation over a median 24-month follow-up. Multivariable analysis showed significantly higher risk of discontinuation among Hispanic (aOR 1.73, 95% CI 1.38-2.18) and NH-Black (aOR 1.36, 95% CI 1.14-1.62) participants, those with age <50 years (aOR 1.46, 95% CI 1.21-1.77), 50-59 years (aOR 1.26, 95% CI 1.05-1.51), or ≥70 years (aOR 1.20, 95% CI 1.03-1.39), participants with higher baseline HbA1c (aOR 1.09 per unit increase, 95% CI 1.06-1.12), or baseline blood pressure ≥140/90 mmHg (aOR 1.24, 95% CI 1.09-1.41), and those in studies with follow-up length 24 to <36 months (aOR 1.64, 95% CI 1.02-2.64) or 36 to 48 months (aOR 2.68, 95% CI 1.87-3.84).
Approximately 15% of participants in the eligible DRCRnet studies discontinued participation. Racial and ethnic identity, age, glycaemic and blood pressure control, and study follow-up duration are significant predictors of participant discontinuation and should be considered when designing future studies.

PMID:
42728351
Bibliographic data and abstract were imported from PubMed on 12 Sep 2026.

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