Macroscopically anisotropic supramolecular materials prepared from an undercooled liquid-crystalline phase of a cholesterol-based low-molecular-weight compound.

Authors

Chia-Hsin Cheng, Yuichiro Watanabe, Takashi Kajitani, Sadaki Samitsu, Kazunori Sugiyasu

Published in

Nature communications. Volume 17. Issue 1. Sep 11, 2026. Epub Sep 11, 2026.

Abstract

Supramolecular bulk materials composed of low-molecular-weight compounds offer a promising pathway toward sustainable materials. However, achieving a macroscopic structural order and tuneable mechanical properties without relying on covalently bonded macromolecular components remains a significant challenge. We develop a supramolecular material derived from a cholesterol-based low-molecular-weight compound, (3β)-cholest-5-en-3-yl dodecylcarbamate, that forms a metastable liquid-crystalline (LC) phase upon quenching from its isotropic melt. The LC phase displays sufficient fluidity at room temperature to permit bulk processing, for example, by compression; the material subsequently undergoes spontaneous crystallization to form a self-standing sheet. By controlling the quenching temperature and the incubation time prior to processing, we succeed in endowing the sheet with molecular ordering that extends beyond the centimetre scale and, as a result, the sheet exhibits anisotropic mechanical properties. These findings establish a design strategy for creating processable, structurally tuneable, bulk materials exclusively from small molecules.

PMID:
42728265
Bibliographic data and abstract were imported from PubMed on 12 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.