Potent Inhibition of Dengue Virus Infection by Synthetic Compound TXD-174 Through Specific Targeting of IL-24.

Authors

Jiajia Han, Weiya Kong, Dan Guo, Shuwen Liu, Xiaodong Tang, Xingang Yao

Published in

Journal of medical virology. Volume 98. Issue 8. Pages e71093.

Abstract

Dengue virus (DENV) infection has emerged as a critical global public health challenge, particularly in tropical and subtropical regions, where it continues to cause high morbidity rates and severe disease risks. Given the current lack of specific antiviral therapies in clinical practice, the development of novel anti-DENV agents represents an urgent medical need. In this study, the antiviral activity of a novel compound, TXD-174, was systematically evaluated. It was found that TXD-174 exhibited significant inhibitory effects against DENV2 in vitro. Notably, viral replication was effectively blocked by TXD-174, while cytotoxicity assessments revealed a favorable therapeutic window. Furthermore, the compound demonstrated inhibitory activity against all four DENV serotypes, highlighting its potential as a broad-spectrum anti-dengue agent. Meanwhile, RNA-seq analysis indicated that level of IL-24 was significantly upregulated. Knockdown of IL-24 gene reduced the antiviral effect of TXD-174, while overexpression of IL-24 gene also exhibited good antiviral effects. In virus-infected AG-129 models, TXD-174 was also found to have good in vivo antiviral effects. These findings establish a foundation for further exploration of targeted therapeutic strategies against DENV infections.

PMID:
42557990
Bibliographic data and abstract were imported from PubMed on 13 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.