Authors
Brian Imbiakha, Hana Janova, Michael S Diamond
Published in
Current opinion in immunology. Volume 97. Pages 102678. Epub Oct 14, 2025.
Abstract
Neurotropic viruses represent a public health challenge due to their ability to cause severe neurological conditions, including meningitis, encephalitis, and paralysis. Although many studies have investigated the immune responses to viral infections in the brain and other nervous system targets, most have focused on the effects of resident cells, such as microglia and astrocytes, and infiltrating immune cells, including neutrophils, monocytes, and T cells. However, emerging evidence has demonstrated that neurons themselves mount antiviral responses that suppress viral replication directly and enhance the inhibitory functions of adjacent glial and infiltrating immune cells. In this review, we discuss the intrinsic and extrinsic antiviral responses of neurons, highlighting mechanisms by which they detect viruses and initiate inhibitory responses to protect the nervous system from viral invasion and injury.
PMID:
41092855
Bibliographic data and abstract were imported from PubMed on 13 Sep 2026.
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