Chemical components with antitumour activity from Inula britannica.

Authors

Wenhao Zhou, Yijie Cai, Xilei Wang, Yijun Tu, Chen Chen, Jianqing Yu

Published in

Phytochemistry. Pages 115083. Sep 12, 2026. Epub Sep 12, 2026.

Abstract

The flowers of Inula britannica L. are widely used for their significant antitumour and anti-inflammatory properties. However, the other parts of the plant, including the stems, leaves and roots, remain underutilised. Herein, 18 compounds, including 5 previously undescribed compounds (1-5), were isolated from these underutilised parts, and their structures were elucidated by HRESIMS, NMR and ECD spectroscopic analyses. Several isolated sesquiterpenes (7-9) exhibited significant inhibitory activity against three tumour cell lines. In addition, eight compounds (2-4, 11, 13 and 16-18) showed synergistic effects in combination with cisplatin in SKOV3 cells. Notably, compound 8 significantly inhibited SKOV3 xenograft tumour growth without apparent toxicity. These findings demonstrate that the underutilised parts of I. britannica contain novel sesquiterpenes with promising antitumour activity, warranting further investigation.

PMID:
42731748
Bibliographic data and abstract were imported from PubMed on 13 Sep 2026.

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