Cerebrospinal Fluid Infection Caused by Mixta calida in a Patient With Sarcoma: Case Report With Whole-Genome Sequencing.

Authors

Yuting Xue, Jiajing Wu, Yufeng Sun, Xiaobo Tian, Xiangyi Liu

Published in

Indian journal of medical microbiology. Pages 101284. Sep 12, 2026. Epub Sep 12, 2026.

Abstract

Mixta calida is a rare environmental Erwiniaceae organism with limited evidence of invasive human infection. We report cerebrospinal fluid infection in a 6-year-old girl with recurrent CIC-rearranged central nervous system sarcoma after neurosurgery, chemotherapy, stem-cell transplantation, and Ommaya reservoir access. Turbid cerebrospinal fluid showed severe neutrophilic inflammation and Gram-negative bacilli with leukocyte phagocytosis. Pure culture yielded an isolate identified by MALDI-TOF mass spectrometry. Four genomic 16S rRNA sequences showed 99.93% identity to the M. calida type strain, and whole-genome ANI was 99.59%. These findings support M. calida as a clinically significant opportunistic pathogen in immunocompromised patients.

PMID:
42731728
Bibliographic data and abstract were imported from PubMed on 13 Sep 2026.

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