[Sentinel node biopsy and lymphatic mapping from a nuclear medicine perspective: principles, methods and experiences in Szeged].

Authors

Zsuzsanna Besenyi, Máté Lázár, László Pávics, Gábor Sipka, István Farkas

Published in

Magyar onkologia. Volume 70. Issue 3. Pages 277-285. Sep 11, 2026. Epub Jul 15, 2026.

Abstract

To summarise the principles, indications, radiopharmaceuticals, preoperative imaging and intraoperative detection methods of sentinel node biopsy (SNB) and lymphatic mapping, and to present the experience of the Department of Nuclear Medicine and Theranostics, University of Szeged.
This review is based on current EANM/SNMMI guidelines, the relevant international literature and institutional data.
SNB has become an accepted component of oncological care in melanoma, breast cancer, gynaecological, urological and head-and-neck malignancies. Lymphoscintigraphy combined with SPECT/CT is mandatory in numerous indications. At the University of Szeged, preoperative isotope-guided sentinel node localisation combined with intraoperative gamma probe-assisted sentinel node biopsy has been performed in nearly 6,000 patients since 1999.
SNB is a multidisciplinary procedure requiring nuclear medicine, surgery and pathology. Hybrid tracers and multimodal intraoperative detection further improve detection rates and reduce false-negative results.

PMID:
42731006
Bibliographic data and abstract were imported from PubMed on 13 Sep 2026.

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