The Human Subiculum and Its Role in Spatiotemporal Memory and Mental Imagery.

Authors

Hye Ja Kang, Maria Jieun Hwang, Ji Sun Kim, Ji Yeon Kim, Marie-Agathe Crampon de Place, Sang Ah Lee

Published in

Hippocampus. Volume 36. Issue 5. Pages e70126.

Abstract

Traditionally viewed as a mere relay station of the hippocampal formation, the subiculum is emerging as a computational hub of the medial temporal lobe, essential for multiplexed neural representations guiding behavior. While foundational animal research has revealed that its sophisticated cytoarchitecture allows for conjunctive coding of spatiotemporal information, our understanding of how such neural properties translate to human cognitive function remains incomplete. The evolutionary expansion of its anterior region and the enhancement of its anatomical complexity and widespread neocortical connectivity imply that the function of the human subiculum may extend beyond the spatial domain. In this review, we examine how the subiculum may serve as a scaffold for goal-directed spatiotemporal computations in humans and speculate on its role in supporting abstract cognitive functions such as mental imagery and episodic simulation.

PMID:
42728737
Bibliographic data and abstract were imported from PubMed on 13 Sep 2026.

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