Authors
Krzysztof Łuszczyński, Magdalena Dec, Aleksander Chodowiec, Marcin Radziszewski, Robert Zdanowski, Monika Szafarowska, Paweł Kamiński, Paweł Włodarski, Anna Lutyńska, Aneta Ścieżyńska
Published in
Expert reviews in molecular medicine. Volume 28. Pages e31. Jun 15, 2026. Epub Jun 15, 2026.
Abstract
The receptor for advanced glycation end-products (RAGE) is a unique multi-ligand member of the immunoglobulin superfamily that exists in both membrane-bound and soluble forms. Under physiological conditions, RAGE expression is low in most tissues; however, it is markedly upregulated in response to tissue injury, inflammation or metabolic stress. Ligand-induced activation of RAGE initiates complex intracellular signalling cascades that regulate inflammation, extracellular matrix remodelling, cell proliferation, survival and migration.
While the contribution of RAGE to diabetes and chronic inflammatory diseases is well established, its role in gynaecological disorders remains insufficiently characterized.
This comprehensive review summarizes current evidence on the involvement of RAGE in the pathogenesis of benign gynaecological disorders, such as endometriosis and polycystic ovary syndrome (PCOS), pregnancy-related complications and malignant neoplasms of the female reproductive tract.
It also discusses emerging therapeutic strategies aimed at targeting the RAGE pathway, highlighting their potential translational relevance in gynaecological practice.
PMID:
42294619
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.
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