Authors
Hitoshi Yamaoka, Haruyuki Nakayama-Imaohji, Hisashi Yamasaki, Ayano Tada, Isanori Horiuchi, Tamiko Nagao, Nafisa Tabassum, Emmanuel Munyeshyaka, Hisataka Goda, Tomomi Kuwahara
Published in
International journal of molecular sciences. Volume 27. Issue 10. May 19, 2026. Epub May 19, 2026.
Abstract
The global prevalence of pulmonary infections caused by non-tuberculous Mycobacteria (NTM), particularly the Mycobacterium avium complex (MAC), is increasing. Since NTM are ubiquitous in moist environments and resistant to standard disinfectants, this study evaluated the efficacy of chlorous acid water (CAW) against them. CAW demonstrated superior sanitizing effects compared to sodium hypochlorite (NaClO), efficiently inactivating NTM at 100 mg/L free available chlorine even in the presence of organic matter, where 1000 mg/L NaClO failed. Instead, subcellular fractionation and protein analysis revealed that CAW penetrates the cell to induce extensive aggregation of internal functional proteins, leading to the rapid collapse of membrane potential and ATP production. Furthermore, CAW exhibited significantly lower cytotoxicity toward human lung-derived A549 cells than NaClO. These results indicate that CAW inactivates NTM effectively by targeting internal protein stability and the respiratory chain, offering a potent and safer disinfection strategy for clinical and domestic environments.
PMID:
42196547
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.
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