Cisplatin-Induced Nephrotoxicity Attenuation by Schizophyllum commune Through Regulating Mitochondria-Associated Signaling, Apoptosis, Autophagy, and PINK1/Parkin-Mediated Mitophagy.

Authors

Yu-Wen Sun, Te-Kai Sun, Wen-Ping Jiang, Guan-Jhong Huang

Published in

International journal of molecular sciences. Volume 27. Issue 12. Jun 11, 2026. Epub Jun 11, 2026.

Abstract

Associated with high morbidity and mortality, cisplatin-induced acute kidney injury (AKI) is a common clinical complication characterized by oxidative stress, inflammation, and mitochondria-associated signaling. Although multiple signaling pathways have been implicated in AKI progression, effective interventions targeting these complex mechanisms are still lacking. As a medicinal fungus with antioxidant and anti-inflammatory properties, Schizophyllum commune (SC) has shown potential biological activities; however, its renoprotective effects in cisplatin-induced AKI remain unclear. Therefore, this study aimed to investigate SC's protective effects and underlying mechanisms in a cisplatin-induced AKI mouse model. SC treatment improved renal function and attenuated histopathological damage. It reduced oxidative stress and inflammatory responses, as evidenced by the modulation of malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO), and pro-inflammatory cytokines. Mechanistically, SC regulated multiple signaling pathways, including mitogen-activated protein kinase (MAPK), toll-like receptor 4/nuclear factor kappa B (TLR4/ NF-κB), PI3K/AKT, nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1), and the calcium/calmodulin-dependent protein kinase kinase-AMP-activated protein kinase-sirtuin 1 (CaMKK-AMPK-Sirt1) axis. In addition, SC modulated apoptosis, autophagy, and PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy, suggesting improved mitochondrial homeostasis. These findings indicate that SC exerts renoprotective effects and may contribute to cisplatin-induced nephrotoxicity mitigation strategies.

PMID:
42353025
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.

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