Retinal waves shape starburst amacrine cell dendrite development through a direction-selective dendritic computation.

Authors

Miah N Pitcher, Aanica S B Gonzales, Raul Habib, Marla B Feller

Published in

Cell reports. Volume 45. Issue 6. Pages 117476. Jun 23, 2026. Epub Jun 01, 2026.

Abstract

During development, dendrites undergo structural plasticity in response to neural activity; however, whether spatiotemporal activity patterns can instruct dendritic growth remains unclear. Prior to vision, the developing mouse retina exhibits spontaneous retinal waves with a nasal propagation bias that mimics forward optic flow. Here, we reveal that starburst amacrine cells use direction-selective dendritic computations to transform this propagation bias into asymmetric dendrite growth, linking activity patterns to structural development.

PMID:
42224079
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.

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