Changes in Motor, Functional Independence, and Gait Recovery After Incomplete Spinal Cord Injury with Transcutaneous Spinal Cord Stimulation: A Randomized Controlled Trial with a Partial Crossover Design.

Authors

Hatice Kumru, Aina Ros-Alsina, Agustín Hernandez-Navarro, Eloy Opisso, Margarita Vallès, Jesus Benito-Penalva, Joan Vidal, Miquel Sarrio, Loreto García-Alén

Published in

Biomedicines. Volume 14. Issue 6. May 27, 2026. Epub May 27, 2026.

Abstract

Background: Transcutaneous spinal cord stimulation (tSCS) is a promising approach to enhance functional recovery after spinal cord injury (SCI). However, evidence on repeated sessions and their effects on gait and lower-limb strength remains limited. This study evaluated the effects of multisegmental tSCS on walking ability, muscle strength, and functional independence in individuals with SCI. Methods: In this randomized controlled trial with a partial crossover design, twelve individuals received tSCS combined with gait rehabilitation, while ten underwent gait rehabilitation alone, for three weeks. Four participants crossed over to the tSCS group after a minimum one-week washout period following the control intervention. We assessed the American Spinal Injury Association Impairment Scale (AIS), Total Motor Score (TMS), Lower Extremity Motor Score (LEMS), Walking Index for Spinal Cord Injury II (WISCI-II), 10- and 6-Meter Walking Tests (10MWT, 6meterWT), Timed Up and Go (TUG) test, maximal voluntary contraction (MVC) of the quadriceps (QM) and tibialis anterior (TA), and the Spinal Cord Independence Measure (SCIM-III); tSCS was applied at three spinal segments during gait rehabilitation over 15 sessions. Results: tSCS significantly improved MVC in both muscles, as well as SCIM-III and TUG, and these improvements were maintained at follow-up, with no significant adverse events reported. Other clinical assessments also showed significant improvement in both groups. Conclusions: tSCS was well tolerated and conferred additional benefits in lower-limb muscle strength, walking ability (as assessed by TUG), and functional independence, supporting its potential as a valuable adjunct to rehabilitation.

PMID:
42351642
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.

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