Authors
Valeria Tudino, Sara Rossi, Leonardo Milioni, Chiara Cosenza, Gabriele Carullo, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Published in
Chemical record (New York, N.Y.). Volume 26. Issue 7. Pages e202500359. Epub May 08, 2026.
Abstract
ESKAPE bacteria represent a global threat to public health. These microorganisms employ a type of cell-cell communicationnamed "quorum sensing (QS) system," which involves the activation of specific signals to modulate drug resistance and pathogenic behaviors. Noteworthy, resistance of Pseudomonas aeruginosa to antibiotics is increasing, thus leading to a greater interest in the development of new antibacterial compounds by exploring valuable targets such as its complex QS system. This review intends to provide an extensive report about the advances in the identification of promising P. aeruginosa QS inhibitors as potential novel therapeutic options. This work represents a comprehensive analysis of research articles available on Pubmed, Scopus, and Google Scholar, from January 2020 to July 2025, referring to promising antivirulence compounds, affecting P. aeruginosa QS system.
PMID:
42101011
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.
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