Authors
Akash Vikal, Rashmi Maurya, Brij Bihari Patel, Preeti Patel, Manish Kumar, Balak Das Kurmi
Published in
Central nervous system agents in medicinal chemistry. Volume 26. Issue 2. Pages 125-149.
Abstract
Cognitive enhancement, aimed at improving or preserving memory, attention, and executive functions, has gained significant interest from both the scientific community and the public. This review explores various strategies for enhancing cognitive function, including natural compounds, synthetic enhancers, and behavioural approaches. Natural compounds like curcumin, Ginkgo biloba, Panax ginseng, and Rhodiola rosea are examined for their cognitive benefits, with ongoing research on their mechanisms and potential nanoformulation-based drug delivery. Synthetic enhancers such as Modafinil, Piracetam, Methylphenidate, and Noopept show promise in improving cognitive functions. Additionally, substances influencing brain metabolism, like Creatine and Coenzyme Q10, are discussed. Behavioural interventions, including sleep optimization, meditation, and physical exercise, are evaluated for their cognitive-enhancing effects. Noninvasive brain stimulation techniques, such as TMS and tDCS, along with innovative methods like whole-body vibration and brain-machine interfaces, are also explored. The review emphasizes the complex interplay of these strategies and the need for continued research to fully exploit their potential. By highlighting natural compounds, synthetic drugs, and behavioural approaches, the review advocates for a multifaceted approach to cognitive enhancement and calls for more detailed and longitudinal studies to understand their long-term benefits and mechanisms.
PMID:
40662561
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.
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