Pediatric ALK-Negative Anaplastic Large Cell Lymphoma With Recurrent Cutaneous Relapses: Diagnostic Challenges.

Authors

Kayla Coffman, Emily Saurborn, Dylan Maldonado, Paul Finch, Shane Cook

Published in

Pediatric dermatology. Sep 13, 2026. Epub Sep 13, 2026.

Abstract

We present the case of a 10-year-old female with anaplastic lymphoma kinase protein (ALK) negative systemic anaplastic large cell lymphoma (ALCL) with cutaneous manifestations that achieved complete remission after multi-agent chemotherapy. Approximately 6 months after remission, the patient experienced a relapse of ALK-negative ALCL confined exclusively to the skin. Four months after completing salvage therapy, she developed a second isolated cutaneous relapse. This case highlights the diagnostic challenge of distinguishing systemic ALCL from primary cutaneous ALCL and other primary cutaneous CD30+ lymphoproliferative disorders.

PMID:
42732905
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.

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