[Empirical Classification of Tri-Allelic Genotype Cases and Parentage Index Calculation].

Authors

Le Yang, He Ren, Yan Shi, Chong Chen, Li Jia, Qian Yang, Yacheng Liu, Jiangwei Yan

Published in

Fa yi xue za zhi. Volume 42. Issue 3. Pages 254-260. Jun 25, 2026.

Abstract

To standardize the calculation method of the parentage index (PI) for short tandem repeat (STR) tri-allelic genotypes, thereby ensuring the accuracy and reliability of parentage tes‑ ting conclusions.
A systematic analysis of 160 real cases was conducted. A classification system was constructed based on the occurrence mechanisms and inheritance patterns of STR tri-alleles, and the PI calculation method was optimized by integrating previous research findings with empirical data.
A mechanism-based classification system for STR tri-allelic genotypes was established, comprising Type I (2 subtypes), Type II (6 subtypes), and the trisomic type (2 subtypes). On this basis, a standardized PI calculation method covering all categories of STR tri-allelic genotypes was developed.
This study provides methodological guidance for the scientific and standardized calculation of PI for STR tri-allelic genotypes and offers an important reference for the formulation and refinement of relevant industry standards.

PMID:
42732986
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.

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