Authors
Satoko Fujimoto, Gregg T Kokame, Ryo Kawasaki, Chikako Hara, Jase N Omizo, Kohji Nishida
Published in
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). Pages 100372. Sep 13, 2026. Epub Sep 13, 2026.
Abstract
To compare clinical characteristics of geographic atrophy (GA) among Caucasians in Hawaii (C-A), Japanese Americans in Hawaii (J-A), and Japanese in Japan (J-J).
Retrospective study.
Consecutive patients with GA were recruited from single institutions in Hawaii and Japan, and GA areas within 6×6mm² OCT scan area were measured on near-infrared images obtained at the latest visit. Ethnic differences in GA-related characteristics were assessed using mixed-effects models adjusted for age and sex. All values are means.
A total of 125 eyes from 91 patients were included: 51 eyes of 36 C-A (58% men), 36 eyes of 26 J-A (35% men), and 38 eyes of 29 J-J (69% men). Bilateral GA was more frequent in C-A (72%) than in J-J (34%, P < 0.01), while J-A (50%) did not differ from either group. The number of GA foci was greater in C-A (2.8) than in J-A (1.9, P < 0.05) and J-J (1.5, P < 0.01). GA area was significantly larger in C-A (10.3mm²) than in J-J (8.8mm², P < 0.05), with J-A (6.0mm²) intermediate. Subfoveal choroidal thickness (SFCT) was thinner in C-A (83.3µm) than in J-A (140.8µm, P < 0.001) and J-J (165.3µm, P < 0.0001).
The number of GA foci and SFCT differed between J-J and C-A as well as between J-A and C-A, suggesting genetic differences. In contrast, significant differences in GA area and bilaterality were observed only between J-J and C-A. The intermediate values in J-A may reflect environmental influences. Further studies are warranted.
PMID:
42732817
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.
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