Domino transformation of silylated enamidonitriles for straightforward access to fully substituted 2,3-diaminofuran derivatives.

Authors

Célia Schwoerer, Pierre Hansjacob, Frédéric R Leroux, Morgan Donnard

Published in

Chemical communications (Cambridge, England). Sep 14, 2026. Epub Sep 14, 2026.

Abstract

Herein, we report an efficient three-step domino synthesis of diverse polysubstituted 2,3-diaminofurans from silylated enamidonitriles in good to excellent yields. The process exploits both vinylsilane and acrylonitrile functionalities, enabling in situ substitution of the newly formed 2-amino group and overcoming the intrinsic instability of unsubstituted aminofurans.

PMID:
42733976
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.

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