Integrated DoE strategy for the development of low-release hydrogels.

Authors

Catherine Nadeau, Sofie Dhondt, Fatma Moawad, Davide Brambilla

Published in

Chemical communications (Cambridge, England). Sep 14, 2026. Epub Sep 14, 2026.

Abstract

A design of experiments approach was used to build a poly(ethylene glycol) diacrylamide (PEGDAAm) hydrogel library and identify the key formulation factors governing protein release. The optimized formulation demonstrated low protein release, and its translational potential was confirmed by loading uricase enzyme, which exhibited low release while maintaining enzymatic activity.

PMID:
42733961
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.

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