Authors
Xinxin Yang, Qingbin Zeng, Jiawei Zhu, Xiuchao Zhao, Zhen Wang, Zhongyu Xiao, Yanling Feng, Yaping Yuan, Chenlu Yuan, Haidong Li, Sa Xiao, Louis-S Bouchard, Xin Zhou, Qianni Guo
Published in
Small (Weinheim an der Bergstrasse, Germany). Pages e75746. Sep 14, 2026. Epub Sep 14, 2026.
Abstract
Metal-organic framework (MOF) films synergize molecular-scale porosity with conformal surface chemistry on polymer substrates. We report a spectrally selective coating in which a ZIF-8 film, seeded by a Zn(II)-polydopamine (Zn-PDA) interlayer on polytetrafluoroethylene (PTFE), enables hyperpolarized 1 2 9Xe MRI detection of the polymer surface, while conventional 1H MRI delineates anatomy. The coating produces a film-bound 1 2 9Xe resonance at 82.0 ppm in both water and fetal bovine serum. After 60 min, the resonance position remained unchanged, with signal-to-noise ratios decreasing by only 14.9% and 17.2%, respectively. Selective excitation yields coating-specific positive contrast on the 1 2 9Xe channel; correspondingly, 1H MRI reveals a distinct surface appearance likely due to altered local proton density and magnetic susceptibility. In phantoms, 1 2 9Xe and 1H images were co-registered with a center-point offset of 0.34 mm; in a flow simulator, the offset was 0.26 mm. A rat airway experiment confirmed in vivo spectral selectivity with a film-bound resonance near 92 ppm, co-localizing with 1 2 9Xe ventilation and 1H anatomical references. While demonstrated here using coated PTFE segments and direct xenon bubbling, these results provide a robust proof of concept for MOF-coated polymers as spectrally selective 1 2 9Xe MRI labels, warranting future physiological translation.
PMID:
42734098
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.
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