Heterogenized (PNNP)Ru Complex Catalyst on Merrifield Resin for Hydrogenation of Unactivated Amides.

Authors

Lukas Blank, Hiryu Takinami, Hiroaki Shibayama, Naoki Noto, Mizuho Yabushita, Keiichi Tomishige, Arash Ghaderi, Susumu Saito

Published in

Inorganic chemistry. Volume 65. Issue 36. Pages 20848-20857. Sep 14, 2026.

Abstract

Hydrogenation of amides with selective C-N bond cleavage over C-O scission remains challenging, especially under heterogenized molecular catalysis. Herein, we report the immobilization of a robust ruthenium complex on the surface of Merrifield resin (RuPCY2@MR) as a highly effective and selective heterogenized organometallic catalyst for the C-N bond cleavage of amides. Characterization of this complex was performed employing different techniques, including ICP-AES, IR, XRF, TGA, XPS, 31P CP/MAS NMR, and SEM. This heterogenized catalyst enables the hydrogenation of different unactivated aromatic and aliphatic amides with excellent selectivity toward C-N scission in up to 99% yield with low catalyst loadings (1 mol %). The heterogeneity of this catalyst was proven by a hot filtration test, and catalyst recycling was performed in up to three cycles.

PMID:
42734382
Bibliographic data and abstract were imported from PubMed on 14 Sep 2026.

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