Screening of Antiviral Agents Against CHIKV Using Reporter Virus.

Authors

Eliana F Castro, Diego Alvarez

Published in

Methods in molecular biology (Clifton, N.J.). Volume 3067. Pages 183-192.

Abstract

Chikungunya virus (CHIKV) causes a disease characterized by chronic musculoskeletal inflammation for which specific antivirals are not yet available. Currently, a supportive therapy to alleviate fever and pain is used, but it does not limit viral replication or the persistence of chronic arthritis symptoms. Thus, the identification and development of new active molecules against CHIKV is urgently needed. Here, we present a cell-based methodology that enables the implementation of a rapid and cost-effective strategy for high- and medium-throughput screening (HTS) of compounds, including repurposed drugs or novel molecules. This methodology allows for the identification of novel antiviral hits with a good activity and selectivity profile against CHIKV.

PMID:
42734798
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

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