Two novel C₂₁ steroidal glycosides from Cynanchum auriculatum.

Authors

Chao Chen, Lu-Yuan Zhang, Hong-Bo Lou, Kai-Liang Pu, Yun-Lu Li, Hai-Rong Lu, Guo-Song Wen, Yong Shen

Published in

Journal of Asian natural products research. Pages 1-10. Sep 14, 2026. Epub Sep 14, 2026.

Abstract

Two new C₂₁ steroidal glycosides, metaplexigenin TC1 (1) and cynanchogenin TC2 (2), were isolated from the roots of Cynanchum auriculatum. Their structures were determined to be meta--plexigenin 3-O-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-cymaropyr-anosyl-(1→4)-β-D-digitoxopyranoside (1) and cynanchogenin 3-O-β-D-cymaropyranos-yl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyr-anoside (2) by IR, HRESIMS and NMR experiments. The in vitro NO release inhibition assays gave IC₅₀ values of 76.5 and 53.0 μmol/L, respectively.

PMID:
42735329
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

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