Authors
Zhe Wang, Jie Qin, Jia Wang, Ze Chen, Ziyu Qiao, Ming Yan, Dahai Wu
Published in
International journal of endocrinology. Volume 2026. Pages 3604933. Epub Apr 16, 2026.
Abstract
This study aimed to evaluate the potential causal association between obstructive sleep apnea (OSA) and the risk of female reproductive endocrine diseases (REDs), including polycystic ovary syndrome (PCOS), endometriosis (EMs), and female infertility (FI) using Mendelian randomization (MR) analysis.
Genome-wide association study (GWAS) summary statistics were obtained from the FinnGen consortium, GWAS catalog, UK Biobank, and GIANT consortium, with a focus on individuals of European ancestry. Single-nucleotide polymorphisms (SNPs) correlated with OSA were investigated in relation to REDs (PCOS, EMs, and FI) using the inverse-variance weighted (IVW) method. Sensitivity analyses were used to test the consistency of the results. Furthermore, a two-step MR was performed to quantify the proportion of the effect of body mass index (BMI)-mediated OSA on REDs.
Our primary MR analysis revealed that genetically predicted OSA was positively linked to increased PCOS (odds ratio [OR] 1.341, 95% confidence interval [CI] 1.014-1.774, p = 0.039), while no significant causal relationships were observed between OSA and EMs, or FI (all p > 0.05). Mediation analysis showed that BMI mediated 18% of the association between OSA and PCOS (OR = 1.053, 95% CI = 1.015-1.105).
This study suggested that early detection and management of OSA in women may be a new strategy to improve PCOS in the future. Meanwhile, it also emphasized the importance of adjusting BMI as a therapeutic strategy to mitigate the effects of OSA on PCOS.
PMID:
42006396
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.
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