Authors
Lara U Jansen, Özge P Burhan, Alexander Hruscha, Janina Tokarz, Cornelia Prehn, Alexander Cecil, Jerzy Adamski, Christian Haass, Ting Sun, Stefan Bonn, Bettina Schmid
Published in
Frontiers in cell and developmental biology. Volume 14. Pages 1789605. Epub Jun 01, 2026.
Abstract
RNA binding proteins have multiple diverse cellular functions and are often mis-regulated in disease. Despite their many cellular functions and implications in disease, very little is known about their physiological functions. Here we describe a novel zebrafish knockout model of the RNA binding proteins Hnrnpa1 and Hnrnpa3. Loss of Hnrnpa3 in zebrafish has no obvious morphological phenotype. Similarly, single mutants of the duplicated zebrafish hnrnpa1 genes, hnrnpa1a and hnrnpa1b, have no discernible phenotype, whereas the hnrnpa1a; hnrnpa1b double mutants are embryonic lethal. They display muscle, vascular and developmental defects with a reduced volume of the yolk extension. Metabolic profiling revealed severe changes in lipid metabolism in the hnrnpa1a; hnrnpa1b double mutants. Our analysis identified the involvement of Hnrnpa1 in many cellular pathways including the regulation of lipid metabolism and opens the door for future therapeutic studies in HNRNPA-associated diseases.
PMID:
42306302
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.
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