The role of abnormal amino acid metabolism in the occurrence and development of tumors.

Authors

Yuting Zhang, Honglin Chen

Published in

Frontiers in oncology. Volume 16. Pages 1759991. Epub Mar 05, 2026.

Abstract

The proliferation, migration, and invasion of tumor cells require a large amount of nutrients. Among them, the uptake of amino acids is crucial for most cellular functions, such as protein synthesis and cell growth. Tumor cells obtain a large number of essential amino acids from the environment through unique metabolic pathways and accelerate the synthesis of non-essential amino acids to meet their own needs. This review summarizes the uptake and utilization of amino acids by tumors and their inhibitory effects on immune cells, providing a basis for targeted metabolism in cancer treatment.

PMID:
41869642
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

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