Authors
Nadim Chaarani, Riyad Mroweh, Razan Moghnieh, Mohammad Kheir Chahine, Hassan Zaiter, Saleh-Yezan Abdulaal, Nazih Obeid, Mohamad Tlais, Joy Raheb, Hadi Farhat, Razan Abdulaal
Published in
World journal of experimental medicine. Volume 16. Issue 1. Pages 116771. Mar 20, 2026. Epub Mar 20, 2026.
Abstract
Atherosclerosis is a progressive inflammatory disease and a major contributor to cardiovascular disease. Resveratrol (RES), a polyphenolic compound found in grapes and red wine, has been widely investigated for its protective effects on cardiovascular health. This review summarizes the mechanisms through which RES attenuates atherosclerosis, including its anti-inflammatory, antioxidant, and lipid-modulating effects. Experimental evidence indicates that RES inhibits nuclear factor kappa-light-chain-enhancer of activated B cells signaling, thereby reducing the expression of adhesion molecules such as vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and limiting immune cell infiltration into the arterial wall. Additionally, it counteracts oxidative stress by enhancing antioxidant enzyme activity and preventing low-density lipoprotein oxidation, a key event in foam cell formation. RES also promotes cholesterol efflux through adenosine triphosphate-binding cassette transporters, supporting high-density lipoprotein-mediated reverse cholesterol transport. Findings from in vitro, animal, and clinical studies suggest that RES can reduce atherosclerotic plaque development, improve endothelial function, and modulate lipid metabolism.
PMID:
41883445
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 9
- Comments 0