Authors
Xingsen Zhao, Liqun Chen, Liangjian Ma, Xiaohui Liu, Zhongkai Cao, Xiangjun Chen, Lidan Hu
Published in
Neural regeneration research. Volume 21. Issue 6. Pages 2543-2552. Jun 01, 2026. Epub Feb 24, 2025.
Abstract
JOURNAL/nrgr/04.03/01300535-202606000-00069/figure1/v/2026-02-11T151048Z/r/image-tiff Alzheimer's disease is the most common cause of dementia. Although increasing evidence suggests that disruptions in lipid metabolism are closely associated with the disease, the overall profile of lipid and sterol changes that occur in the brain during Alzheimer's disease remains unclear. In this study, we compared brain tissues extracted from 32-week-old male wild-type mice and 5×FAD transgenic Alzheimer's disease model mice, which carry mutations in the amyloid precursor protein ( APP ) and presenilin 1 ( PS1 ) genes. Using untargeted lipidomics and sterolomics techniques, we investigated the metabolic profiles of lipids, with a focus on sterols specifically, in three brain regions: cerebellum, hippocampus, and olfactory bulb. Our results revealed significant alterations in various lipids, particularly in the hippocampus and olfactory bulb, suggesting changes in energy levels in these regions. Further pathway analysis indicated notable disruptions in key metabolic processes, particularly those related to fatty acids and cell membrane components. Additionally, we observed decreased expression of 15 genes involved in lipid and sterol regulation. Collectively, these findings provide new insights into how imbalances in lipid and sterol metabolism may contribute to the progression of Alzheimer's disease, highlighting potential metabolic pathways involved in the development of this debilitating disease.
PMID:
40150820
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.
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