Functional roles and clinical implications of pseudogenes signatures as emerging biomarkers in cancer.

Authors

Mohamed Bakr Zaki, Nadia M Hamdy, Mai A Abd-Elmawla, Nehal I Rizk, Doaa Fathi, Nourhan M Abdelmaksoud, Rehab A Ismail, Ahmed S Doghish, Ahmed I Abulsoud

Published in

Discover oncology. Volume 17. Issue 1. Aug 06, 2026. Epub Aug 06, 2026.

Abstract

Pseudogenes' possible functions in gene control and illness have now come to light. However, it has been recognized that numerous pseudogenes play a critical role in the regulation of their respective parent genes, and it is well-established that pseudogenes influence oncogenes and tumor suppressors. Moreover, pseudogenes are being emphasized for their possible use as diagnostic cancer and prognostic biomarkers. Defining, contextualizing, classifying, and discussing the evolutionary relevance of pseudogenes are all aspects of their complex nature that this article explores. An examination of the clustering and co-expression patterns of pseudogenes, as well as the potential regulatory tasks they may perform, is undertaken. This review seeks to investigate the implications of pseudogenes in various cancer types. Pseudogenes' evolution, biogenesis, and classifications, with in silico analysis, will be reported comprehensively. Additionally, the current review will enumerate the potential of pseudogenes as diagnostic biomarkers and their prognostic significance (good vs. bad) in different cancers. The review elucidated their various functions in cancer and concluded the need for further research to fully understand the roles of pseudogenes in health and disease.

PMID:
42562996
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

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