The roles of the microtubule cytoskeletal network in cardiac mechanobiology.

Authors

Jack F Murphy, Xuan Li

Published in

Journal of cell science. Volume 139. Issue 6. Mar 15, 2026. Epub Mar 23, 2026.

Abstract

The intracellular cytoskeletal network is a central mediator of mechanobiology, transmitting extracellular cues from the cell membrane to elicit downstream changes in cell behaviour and morphology. In cardiomyocytes, mechanotransduction via the intracellular cytoskeleton plays a pivotal role in regulating cardiac output, development and pathological remodelling. Various structural components contribute to this process, including tension-mediated ion channels, contractile sarcomere units, transmembrane cell junction proteins, intermediate filaments and the microtubule network. Among these components, microtubules are the largest and most rigid cytoskeletal elements. This Review highlights the essential, but often understated, role of microtubules in cardiomyocyte mechanobiology, particularly in their coordination with other cytoskeletal elements. Furthermore, this Review highlights how the microtubule cytoskeletal network is connected to cardiac disease phenotypes.

PMID:
41873788
Bibliographic data and abstract were imported from PubMed on 15 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.